rattlesnakes
Of the 25 species of snakes in Colorado, only two are venemous: the western rattlesnake, which lives almost everywhere, and the massasauga, which is limited to the grassy lands of the Eastern Plains. If you are afraid of snakes, head for the cool, highest elevations of the Rockies. Western rattlers can't live above 7,500 to 9,500 ft 2134 to 2743 m.
Rattlesnakes are more afraid of you than you are of them. If you hear a rattle, it's a warning. Freeze and look around for the snake. Move cautiously away from the snake once you locate it, even if it means cutting your hike short.
Do not try to kill or further antagonize the snake, as this may lead to additional bites.
If you are bitten, the good news is that you almost certainly will live through the painful experience. Remain as calm as possible. Rattlesnake venom is essentially digestive enzymes, and will break down tissue around the bite. Try not to move much which spreads the venom unless you must do so. Painful swelling of lymph nodes in the groin or armpit usually occurs within one hour if the bite is on the leg or arm. Call emergency medical services 911 and/or a poison control center. There is antivenin available for use against all native pit vipers in the US.
outdoors
Dehydration is a serious concern. The aridity of the air is deceptive--you will perspire and exhale moisture from your mouth and nose without even realizing it. If you're going to hike anywhere in Colorado, take plenty of water at least one gallon per person, per day, decent nonslip boots or sneakers, as well as layers of clothing. Always hike with a waterproof jacket--more people die of hypothermia in Colorado in the summer simply by being caught unawares. Let people know where you are going and when you expect to get back.
Be careful and watch for lightning while hiking, especially in the high country. It's often best to hike in the early morning to avoid the possibility of hitting an afternoon thunderstorm.